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Remifentanil is relatively context insensitive whilst fentanyl and thiopentone are examples of drugs which have significant context-sensitive changes in their half-life. [1] The Context-Sensitive Half-Time describes the time required for the plasma drug concentration to decline by 50% after terminating an infusion of a particular duration. [2]
Remifentanil's short context-sensitive half-life makes it ideal for intense pain of short duration. As such, it has been used for analgesia in labor successfully; however, it is not as effective as epidural analgesia. [10] In combination with propofol, remifentanil is used for anesthesia of patients undergoing electroconvulsive therapy. [11]
Remifentanil: 100–200 50–100 μg 0.05 (3–6 min context-sensitive half-life; 7–18 min elimination half-life) Instantaneously (from 5 to 15 sec) 15 minutes; rapid offset of effects necessitates continuous infusion for maintenance of anesthesia Protonitazene: 200 50 μg Ocfentanil: 125–250 40–80 μg Ro4-1539: 240–480 20–40 μg
The last image we have of Patrick Cagey is of his first moments as a free man. He has just walked out of a 30-day drug treatment center in Georgetown, Kentucky, dressed in gym clothes and carrying a Nike duffel bag.
Remifentanilic acid is a metabolite of the potent short-acting synthetic opioid analgesic drug remifentanil. It is an analog of fentanyl and remifentanil , but is not active as an opioid in its own right.
Thiopental is not used by infusion becuase of it's Context Sensitive Half Time (CSHT). ie. The longer the infusion continues (time = context), the more drug deposited in preipheral tissues. When the infusion is stopped, the drug re-distributes to the plasma, continuing the effect (they take a much longer time to wake up).
Houseplants. Indoor plants can still release pollen, sap, or spores, and can also collect mold and dust. Symptoms of a plant allergy may include runny nose; itchy eyes, throat, and/or ears; skin ...
Anamaria Baralt, the cousin of Lyle and Erik Menendez, is among more than 20 family members advocating for their release in Washington, D.C., on Jan. 23, 2025.