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Medroxyprogesterone acetate (MPA), also known as depot medroxyprogesterone acetate (DMPA) in injectable form and sold under the brand name Depo-Provera among others, is a hormonal medication of the progestin type. [10] [4] It is used as a method of birth control and as a part of menopausal hormone therapy.
Estradiol/medroxyprogesterone acetate (E2/MPA), sold under the brand names Indivina and Tridestra among others, is a combination product of estradiol, an estrogen, and medroxyprogesterone acetate, a progestogen, which is used in menopausal hormone therapy for the treatment of menopausal symptoms. [1]
Polyestradiol phosphate/medroxyprogesterone acetate (PEP/MPA) is a combination of polyestradiol phosphate (PEP), an estrogen, and medroxyprogesterone acetate (MPA), a progestin, which was studied in the 1960s as a long-lasting combined injectable contraceptive for women but was never marketed.
Medroxyprogesterone, also known as 6α-methyl-17α-hydroxyprogesterone or as 6α-methyl-17α-hydroxypregn-4-en-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone. [ 2 ] [ 3 ] It is specifically a derivative of 17α-hydroxyprogesterone with a methyl group at the C6α position.
[39] [37] Estrogen plus oral progesterone has been found to significantly improve quality of life. [39] [37] The combination of an estrogen and 100 to 300 mg/day oral progesterone has been found to improve sleep outcomes. [39] [37] [47] Moreover, sleep was improved to a significantly better extent than estrogen plus medroxyprogesterone acetate ...
Melissa Mondala, MD, an expert in women’s nutrition, suggests incorporating foods that are proven to have a positive effect on mood into your diet. “Foods high in omega-3 and healthy fats may ...
Major examples of progestins include the 17α-hydroxyprogesterone derivative medroxyprogesterone acetate and the 19-nortestosterone derivative norethisterone. The progestins are structural analogues of progesterone and have progestogenic activity similarly, but differ from progesterone in their pharmacological properties in various ways. [5]
[48] [50] [59] A 2016 systematic review found based on limited evidence from 6 studies that hormonal birth control, including combined birth control pills, depot medroxyprogesterone acetate, and levonorgestrel-containing intrauterine devices, was not associated with worse outcomes compared to non-use in women with depressive or bipolar ...