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Mono is primarily diagnosed based on the symptoms and can be confirmed with blood tests for specific antibodies. [3] Another typical finding is increased blood lymphocytes of which more than 10% are reactive. [3] [9] The monospot test is not recommended for general use due to poor accuracy. [10]
The test is usually performed using commercially available test kits which detect the reaction of heterophile antibodies in a person's blood sample with horse or cow red blood cell antigens. These test kits work on the principles of latex agglutination or immunochromatography. Using this method, the test can be performed by individuals without ...
In the infectious stage of this illness, individuals will have Epstein Barr viral capsid antigens (EBV-VCA) in their mouth and blood. [1] [2] The viral capsid of a virus is the complex of proteins that surrounds the genetic material inside the virus. Epstein Barr virus capsid antigens (VCA) are any sections of the viral capsid that the hosts ...
Blood test results for persons with infectious mononucleosis include an elevated white blood cell count, an increased percentage of atypical mononuclear cells. Liver enzymes are often elevated. A positive "mono spot" test is useful in confirming the diagnosis but a negative result does not rule out primary EBV infection.
Heterophile antibodies are IgM antibodies with affinity for sheep and horse red blood cells. They appear during the first week of infectious mononucleosis symptoms, 3–4 weeks after infection and return to undetectable levels 3 to 6 months after infection. Heterophile antibody is a fairly specific but insensitive test for EBV.
A white blood cell differential is a medical laboratory test that provides information about the types and amounts of white blood cells in a person's blood. The test, which is usually ordered as part of a complete blood count (CBC), measures the amounts of the five normal white blood cell types – neutrophils, lymphocytes, monocytes, eosinophils and basophils – as well as abnormal cell ...
Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell dyscrasia in which plasma cells or other types of antibody-producing cells secrete a myeloma protein, i.e. an abnormal antibody, into the blood; this abnormal protein is usually found during standard laboratory blood or urine tests.
Reference ranges (reference intervals) for blood tests are sets of values used by a health professional to interpret a set of medical test results from blood samples. Reference ranges for blood tests are studied within the field of clinical chemistry (also known as "clinical biochemistry", "chemical pathology" or "pure blood chemistry"), the ...