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Also, collagen IV lacks the regular glycine in every third residue necessary for the tight, collagen helix. This makes the overall arrangement more sloppy with kinks. These two features cause the collagen to form in a sheet, the form of the basal lamina. Collagen IV is the more common usage, as opposed to the older terminology of "type-IV ...
12829 Ensembl ENSG00000081052 ENSMUSG00000067158 UniProt P53420 Q9QZR9 RefSeq (mRNA) NM_000092 NM_007735 RefSeq (protein) NP_000083 NP_031761 Location (UCSC) Chr 2: 227 – 227.16 Mb Chr 1: 82.43 – 82.56 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Collagen alpha-4(IV) chain is a protein that in humans is encoded by the COL4A4 gene. This gene encodes one of the six subunits of ...
In molecular biology, the type IV collagen C4 domain (or collagen IV NC1 domain) is a duplicated domain present at the C-terminus of type IV collagens.Each type IV collagen contains a long triple-helical collagenous domain flanked by a short 7S domain of 25 amino acids and a globular non-collagenous C4 domain of ~230 amino acids at the N and C terminus, respectively.
Collagen is also abundant in corneas, blood vessels, the gut, intervertebral discs, and the dentin in teeth. [3] In muscle tissue, it serves as a major component of the endomysium. Collagen constitutes 1% to 2% of muscle tissue and 6% by weight of skeletal muscle. [4] The fibroblast is the most common cell creating collagen in animals.
Collagen alpha-1(IV) chain (COL4A1) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. [ 5 ] [ 6 ] It is ubiquitously expressed in many tissues and cell types. [ 7 ] COL4A1 is a subunit of the type IV collagen and plays a role in angiogenesis . [ 8 ]
1285 12828 Ensembl ENSG00000169031 ENSMUSG00000079465 UniProt Q01955 Q9QZS0 RefSeq (mRNA) NM_000091 NM_031362 NM_031363 NM_031364 NM_031365 NM_031366 NM_007734 RefSeq (protein) NP_000082 NP_031760 Location (UCSC) Chr 2: 227.16 – 227.31 Mb Chr 1: 82.56 – 82.7 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Collagen alpha-3(IV) chain is a protein that in humans is encoded by the ...
Collagen alpha-2(IV) chain is a protein that in humans is encoded by the COL4A2 gene. [5] [6] [7] This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members ...
Collagen alpha-5(IV) chain is a protein that in humans is encoded by the COL4A5 gene. This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV ...