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  2. Mitophagy - Wikipedia

    en.wikipedia.org/wiki/Mitophagy

    Damaged mitochondria cause a depletion in ATP and a release of cytochrome c, which leads to activation of caspases and onset of apoptosis. Mitochondrial damage is not caused solely by oxidative stress or disease processes; normal mitochondria will eventually accumulate oxidative damage hallmarks overtime, which can be deleterious to ...

  3. Cell damage - Wikipedia

    en.wikipedia.org/wiki/Cell_damage

    Cell damage (also known as cell injury) is a variety of changes of stress that a cell suffers due to external as well as internal environmental changes. Amongst other causes, this can be due to physical, chemical, infectious, biological, nutritional or immunological factors. Cell damage can be reversible or irreversible.

  4. Regeneration (biology) - Wikipedia

    en.wikipedia.org/wiki/Regeneration_(biology)

    Regeneration in biology is the process of renewal, restoration, and tissue growth that makes genomes, cells, organisms, and ecosystems resilient to natural fluctuations or events that cause disturbance or damage. [1] Every species is capable of regeneration, from bacteria to humans.

  5. Granzyme - Wikipedia

    en.wikipedia.org/wiki/Granzyme

    Granzyme B also cleaves the protein Bid, which recruits the proteins Bax and Bak to change the membrane permeability of the mitochondria, causing the release of cytochrome c (which is one of the parts needed to activate caspase-9 via the apoptosome), Smac/Diablo and Omi/HtrA2 (which suppress the inhibitor of apoptosis proteins (IAPs)), among ...

  6. Mitochondrial theory of ageing - Wikipedia

    en.wikipedia.org/wiki/Mitochondrial_theory_of_ageing

    He found ROS as the main cause of damage to macromolecules, known as "ageing". He later modified his theory because he found that mitochondria were producing and being damaged by ROS, leading him to the conclusion that mitochondria determine ageing. In 1972, he published his theory in the Journal of the American Geriatrics Society. [20]

  7. Skin repair - Wikipedia

    en.wikipedia.org/wiki/Skin_repair

    In the event of an injury that damages the skin's protective barrier, the body triggers a response called wound healing. After hemostasis, inflammation white blood cells, including phagocytic macrophages arrive at the injury site. Once the invading microorganisms have been brought under control, the skin proceeds to heal itself.

  8. Microbial biodegradation - Wikipedia

    en.wikipedia.org/wiki/Microbial_biodegradation

    Microbial biodegradation is the use of bioremediation and biotransformation methods to harness the naturally occurring ability of microbial xenobiotic metabolism to degrade, transform or accumulate environmental pollutants, including hydrocarbons (e.g. oil), polychlorinated biphenyls (PCBs), polyaromatic hydrocarbons (PAHs), heterocyclic compounds (such as pyridine or quinoline ...

  9. Toll-like receptor 9 - Wikipedia

    en.wikipedia.org/wiki/Toll-like_receptor_9

    However, mitochondria that escape digestion via the lysosome/autophagy pathway can activate TLR9-induced inflammation via the NF-κB pathway. TLR9 expression in hearts with pressure overload leads to increased inflammation due to damaged mitochondria and activation of the CpG binding site on TLR9.