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The syndrome is believed to be the main cause of death as a result of fentanyl overdoses. [ 76 ] Wooden chest syndrome is reversed by naloxone and is believed to be caused by a release of noradrenaline , which activates α-adrenergic receptors and also possibly via activation of cholinergic receptors .
Fentanyl overdose is now the number one cause of death for Americans 18-45. The synthetic opioid is usually manufactured in foreign labs, smuggled into the US and often mixed with other street drugs.
The substance may cause harmful effects on the central nervous system and heart, resulting in dysrhythmia, seizures, and coma. [64] The kidneys may be affected as well. Long-term or repeated exposure of the substance may have harmful effects on the liver and kidneys. [65] There is no evidence that phenol causes cancer in humans. [66]
4-Phenylfentanyl is an opioid analgesic that is a derivative of fentanyl.It was developed during the course of research that ultimately resulted in super-potent opioid derivatives such as carfentanil, though it is a substantially less potent analogue. 4-Phenylfentanyl is around eight times the potency of fentanyl in analgesic tests on animals, but more complex 4-heteroaryl derivatives such as ...
The Times story also cited a buprenorphine study by researchers in Sweden that looked at “100 autopsies where buprenorphine had been detected.” According to the Times, the study found that “in two-thirds, it was the direct cause of death, mostly in combination with other drugs.” It was a misreading of the study.
This is a list of fentanyl analogues (sometimes referred to as Fentalogs), [1] [2] [3] including both compounds developed by pharmaceutical companies for legitimate medical use, and those which have been sold as designer drugs and reported to national drug control agencies such as the DEA, or transnational agencies such as the EMCDDA and UNODC.
In law, medicine, and statistics, cause of death is an official determination of the conditions resulting in a human's death, which may be recorded on a death certificate. A cause of death is determined by a medical examiner. In rare cases, an autopsy needs to be performed by a pathologist. The cause of death is a specific disease or injury, in ...
Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening.