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Participants taking semaglutide lost almost 15 percent of their body weight. Those taking the placebo lost about 2.5 percent. More recent papers back this up and show benefits beyond weight loss.
The maximum semaglutide dose for weight loss is 2.4 milligrams (mg) per week. Your healthcare provider will start you on a lower weekly dose and gradually increase it over time.
Participants took once-weekly 2.4-milligram (mg) semaglutide injections or a placebo for 68 weeks and followed healthy lifestyle changes like eating a nutritious diet and increased physical activity.
HbA1c was significantly improved compared to cagrilintide alone and non-significantly better than semaglutide alone. [1] [2] In a Phase II trial, weight loss averaged -15.6 percent after 32 weeks, making CagriSema comparable in efficacy to tirzepatide. [3] [4] A future trial sponsored by Novo Nordisk is comparing tirzepatide and CagriSema head ...
In clinical trials of Wegovy, which included a higher dose of injectable semaglutide (2.4 mg), people lost an average of almost 15 percent of their body weight.
The trials occurred at 129 sites in 16 countries in Asia, Europe, North America, and South America. The mean percentage change in body weight at week 68 was −14.9% in the semaglutide group vs −2.4% with placebo, for an estimated treatment difference of −12.4 percentage points (95% CI, −13.4 to −11.5). [60] [61] [62] [63]
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