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Darier's disease (DD) is a rare, genetic skin disorder. It is an autosomal dominant disorder, that is, if one parent has DD, there is a 50% chance than a child will inherit DD. It was first reported by French dermatologist Ferdinand-Jean Darier in 1889.
Darier's sign is a change observed after stroking lesions on the skin of a person with systemic mastocytosis or urticaria pigmentosa. [1] In general, the skin becomes swollen, itchy and red. This is a result of compression of mast cells, which are hyperactive in these diseases. These mast cells release inflammatory granules which contain ...
From 1909 to 1922, Darier was head of the clinical department at the Hôpital Saint-Louis. [5] He was one of the "big five" of the Paris School of Dermatology, along with Ernest Henri Besnier (1831–1909), Louis-Anne-Jean Brocq (1856–1928), Raymond Sabouraud (1864–1938) and Jean Alfred Fournier (1832–1915).
It is mental suffering; mental torment." [ 1 ] There are numerous ways psychological pain is referred to, using a different word usually reflects an emphasis on a particular aspect of mind life. Technical terms include algopsychalia and psychalgia , [ 2 ] but it may also be called mental pain, [ 3 ] [ 4 ] emotional pain, [ 5 ] psychic pain, [ 6 ...
1) a separation of the traits related to three aspects of activities: social-verbal, motor-physical and mental aspects of behaviour. In contrast to that, all other models of a structure of temperament describing an energetic dimension (for example, traits of Activity or Extraversion) do not differentiate between the traits regulating physical ...
[192] [193] A large-scale meta-analysis (n > 75,000) examining the relationship between all of the Big Five personality traits and common mental disorders found that low conscientiousness yielded consistently strong effects for each common mental disorder examined (i.e., MDD, dysthymic disorder, GAD, PTSD, panic disorder, agoraphobia, social ...
The final STQ-77/FET framework classifies temperament traits and their neurochemical biomarkers into 12 components: nine components regulating the formal functional aspects of behaviour (energetic, dynamic and orientational) each assessed in three domains (intellectual, physical and social-verbal); also three components related to emotionality (Neuroticism, Impulsivity and Satisfaction (Self ...
The cause of the disease is a haploinsufficiency of the enzyme ATP2C1; [7] the ATP2C1 gene is located on chromosome 3, which encodes the protein hSPCA1.A mutation on one copy of the gene causes only half of this necessary protein to be made and the cells of the skin do not adhere together properly due to malformation of intercellular desmosomes, causing acantholysis, blisters and rashes.