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  2. Calcitonin - Wikipedia

    en.wikipedia.org/wiki/Calcitonin

    Other effects are in preventing postprandial hypercalcemia resulting from absorption of Ca 2+. Also, calcitonin inhibits food intake in rats and monkeys, and may have CNS action involving the regulation of feeding and appetite. Calcitonin lowers blood calcium and phosphorus mainly through its inhibition of osteoclasts.

  3. Bone resorption - Wikipedia

    en.wikipedia.org/wiki/Bone_resorption

    Calcitonin is a hormone secreted by the thyroid in humans. Calcitonin decreases osteoclast activity, and decreases the formation of new osteoclasts, resulting in decreased resorption. [4] Calcitonin has a greater effect in young children than in adults, and plays a smaller role in bone remodeling than PTH. [4]

  4. Hypercalcaemia - Wikipedia

    en.wikipedia.org/wiki/Hypercalcaemia

    PTHrP acts similarly to parathyroid hormone in that it binds to the parathyroid hormone 1 receptors on the kidneys and bones and causes an increased tubular reabsorption of calcium and activation of osteoclast activity, respectively. [22] Osteoclasts are a type of bone cell which cause bone resorption, releasing calcium into the bloodstream.

  5. Parafollicular cell - Wikipedia

    en.wikipedia.org/wiki/Parafollicular_cell

    Parafollicular cells secrete calcitonin, a hormone that participates in the regulation of calcium metabolism. Calcitonin lowers blood levels of calcium by inhibiting the resorption of bone by osteoclasts , and its secretion is increased proportionally with the concentration of calcium.

  6. Osteoporosis - Wikipedia

    en.wikipedia.org/wiki/Osteoporosis

    The role of calcitonin, a hormone generated by the thyroid that increases bone deposition, is less clear and probably not as significant as that of PTH. [36] The activation of osteoclasts is regulated by various molecular signals, of which RANKL (receptor activator of nuclear factor kappa-B ligand) is one of the best-studied. [100]

  7. Bisphosphonate - Wikipedia

    en.wikipedia.org/wiki/Bisphosphonate

    Bisphosphonate molecules then attach to and enter osteoclasts where they disrupt intracellular enzymatic functions needed for bone resorption. [38] There are two classes of bisphosphonate compounds: non-nitrogenous (no nitrogen in R 2) and nitrogenous (R 2 contains nitrogen). The two types of bisphosphonates work differently in inhibiting ...

  8. Calcitonin receptor - Wikipedia

    en.wikipedia.org/wiki/Calcitonin_receptor

    The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, [5] particularly with respect to bone formation and metabolism. [6] [7] [8]

  9. Osteoclast - Wikipedia

    en.wikipedia.org/wiki/Osteoclast

    An osteoclast is a large multinucleated cell and human osteoclasts on bone typically have four nuclei [5] and are 150–200 μm in diameter. When osteoclast-inducing cytokines are used to convert macrophages to osteoclasts, very large cells that may reach 100 μm in diameter occur. These may have dozens of nuclei, and typically express major ...