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Dexamethasone is a fluorinated glucocorticoid medication [10] used to treat rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive pulmonary disease (COPD), croup, brain swelling, eye pain following eye surgery, superior vena cava syndrome (a complication of some forms of cancer), [11] and along with antibiotics in tuberculosis. [10]
There is robust evidence that a single course of antenatal corticosteroids (i.e., 24 mg of betamethasone or dexamethasone), when there is a risk of preterm birth (at less than 34 weeks of gestation), reduces the risk of child death, regardless of resource level. [1] [6]
Long-acting glucocorticoids: Betamethasone 0.6 25–40 0 36–72 [25] [26] [27] Dexamethasone 0.75 30 0 36–72 [25] [26] Mineralocorticoids: Fludrocortisone 2 10 250 18–36 [25] [26] Desoxycorticosterone acetate 0 20 1 Activity is relative to hydrocortisone
Prednisone Dexamethasone. ... and research has been focused on the development of effective and safe anti-IL-2 antibodies. ... long term allergic asthma control).
[6] [7] [8] Applying once daily is enough as it is as effective as twice or more daily application. [13] Strong steroids should be avoided on sensitive sites such as the face, groin and armpits. Even the application of weaker or safer steroids should be limited to less than two weeks on those sites.
While effective when given by injection, or by inhalation, giving the medication by mouth is preferred. [4] A single dose is usually all that is required, and is generally considered to be quite safe. [4] Dexamethasone at doses of 0.15, 0.3 and 0.6 mg/kg appear to be all equally effective. [16]
Dexamethasone acts as an anti-inflammatory corticosteroid. [1] In 2022, it was the 286th most commonly prescribed medication in the United States, with more than 500,000 prescriptions. [ 3 ] [ 4 ]
Dexamethasone (Decadron) is given in low dose at the onset of a general anesthetic as an effective antiemetic. It is also used in chemotherapy as a single drug as well as with other antiemetics such as 5-HT 3 receptor antagonists and NK1 receptor antagonist, but the specific mechanism of action is not fully understood.
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