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Modafinil, sold under the brand name Provigil among others, is a central nervous system (CNS) stimulant and eugeroic (wakefulness promoter) medication used primarily to treat narcolepsy, [3] [8] [15] a sleep disorder characterized by excessive daytime sleepiness and sudden sleep attacks. [16]
Clinical pharmacokinetics of methamphetamine [12] Route Dose Bioavailability C max (g/L) Tmax (minutes) T 1/2 (hours) Time to peak effect (minutes) Intravenous 30 mg 100% 108 22 6 9.1 0.8 15 Oral 30 mg 67% 94.1 216 9.1 18 2 Smoking 30 mg 67%/ 90 10% 47 6 150 30 12 1 180 Intra-nasal 50 mg 79% 113 8 169 8 11 1 15
At steady state, the systemic exposure for armodafinil is 1.8 times the exposure observed after a single dose. The concentration-time profiles of the (R)-(−)-enantiomer following a single dose of 50 mg Nuvigil or 100 mg Provigil (modafinil being a 1:1 mixture of (R)-(−)- and (S)-(−)- enantiomers
Methamphetamine accounts for 84% of illegal drug use in Japan and has a relatively high street value in the country (around 10 times the street value in production regions). [18] Netherlands: Unenforced: Illegal: Illegal: Illegal: Methamphetamine is not approved for medical use in The Netherlands. It falls under Schedule I of the Opium Act. [19]
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The botulinum toxin as the most toxic substance known has an LD 50 value of 1 ng/kg, while the most non-toxic substance water has an LD 50 value of more than 90 g/kg; a difference of about 1 in 100 billion, or 11 orders of magnitude. As with all measured values that differ by many orders of magnitude, a logarithmic view is advisable.
A Riverside County Sheriff's Department sting operation gone wrong last week put 60 pounds of methamphetamine in the hands of a narcotics trafficker, the department has admitted.
In 2012, 16,000 prescriptions for methamphetamine were filled, approximately 1.2 million Americans reported using it in the past year, and 440,000 reported using the drug in the past month. [2] Until the 1980s, the methamphetamine market in the United States was dominated by outlaw motorcycle gangs, namely the Hells Angels.