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The U.S. Food and Drug Administration (FDA) notified healthcare professionals of updates to the prescribing information concerning interactions between protease inhibitors and certain statin drugs. Protease inhibitors and statins taken together may increase the blood levels of statins and increase the risk for muscle injury (myopathy).
Rosuvastatin, sold under the brand name Crestor among others, is a statin medication, used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. [6] It is recommended to be used together with dietary changes, exercise, and weight loss. [ 6 ]
AstraZeneca (NYS: AZN) just lost a potential marketing edge for Crestor. In trial results announced today, the statin drug failed to best Lipitor at clearing clogged arteries, at least in a ...
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Type 2 statins form polar interaction between the fluorine atom on the fluorophenyl group and the guanidinium group of Arg 590. [11] In addition to these interactions atorvastatin and rosuvastatin also form unique hydrogen bonds between Ser 565 residue and either a carbonyl oxygen atom (atorvastatin) or a sulfone oxygen atom
A new way of determining heart disease risk may result in millions fewer people getting prescriptions for statins, according to new research. Heart doctors warned, however, that more information ...