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Glutathione S-transferase A3 is an enzyme that in humans is encoded by the GSTA3 gene. [5] [6] [7] Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds.
2941 n/a Ensembl ENSG00000170899 n/a UniProt O15217 n/a RefSeq (mRNA) NM_001512 n/a RefSeq (protein) NP_001503 n/a Location (UCSC) Chr 6: 52.98 – 53 Mb n/a PubMed search n/a Wikidata View/Edit Human Glutathione S-transferase A4, also known as GSTA4, is an enzyme which in humans is encoded by the GSTA4 gene. Function Cytosolic and membrane-bound forms of glutathione S-transferase are encoded ...
[12] [13] Therefore, if a human glutathione S-transferase is a homodimer in the pi-class subfamily 1, its name will be written as "hGSTP1-1." The early nomenclature for GSTs referred to them as “Y” proteins, referring to their separation in the “Y” fraction (as opposed to the “X and Z” fractions) using Sephadex G75 chromatography. [14]
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Glutathione S-transferase theta-1 is an enzyme that in humans is encoded by the GSTT1 gene. [2] Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes ...
Glutathione synthetase deficiency has an autosomal recessive pattern of inheritance. Mutations in the GSS gene cause glutathione synthetase deficiency. This gene provides instructions for making the enzyme glutathione synthetase. This enzyme is involved in a process called the gamma-glutamyl cycle, which takes place in most of the body's cells ...
Glutathione S-transferase omega-1 is an enzyme that in humans is encoded by the GSTO1 gene. [5] [6] [7] This gene encodes a member of the theta class glutathione S-transferase-like (GSTTL) protein family. In mouse, the encoded protein acts as a small stress response protein, likely involved in cellular redox homeostasis. [7]
Glutathione S-transferase kappa 1 (GSTK1) is an enzyme that in humans is encoded by the GSTK1 gene which is located on chromosome seven. [5] It belongs to the superfamily of enzymes known as glutathione S-transferase (GST), which are mainly known for cellular detoxification . [ 6 ]