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Carnosine (β-alanyl-L-histidine), and its topical prodrug formulation N-acetylcarnosine (NAC), is advertised (especially on the internet) to treat a range of ophthalmic disorders associated with oxidative stress, including age-related and diabetic cataracts. No convincing animal studies or masked clinical trials have been reported.
In the United States, age-related lens changes have been reported in 42% between the ages of 52 and 64, [70] 60% between the ages 65 and 74, [71] and 91% between the ages of 75 and 85. [70] Cataracts affect nearly 22 million Americans age 40 and older. By age 80, more than half of all Americans have cataracts.
Researchers have recently developed a new drug that will ultimately shrink down and dissolve cataracts -- the leading cause of human blindness that affects tens of millions of people worldwide. ...
The Age-Related Eye Disease Study (AREDS) was a clinical trial sponsored by the National Eye Institute that ran from 1992 to 2001. [1] The study was designed to: investigate the natural history and risk factors of age-related macular degeneration (AMD) and cataracts , and
Childhood cataracts are the primary cause of childhood blindness. [4] Childhood cataracts make up 7.4% to 15.3% of blindness in kids. [4] The prevalence of childhood cataracts ranges from 0.63/10,000 to 9.74/10,000 children, with a median of 1.71. [6] This is dependent on factors like economic status but not gender or laterality. [6]
Carnosine (beta-alanyl-L-histidine) is a dipeptide molecule, made up of the amino acids beta-alanine and histidine.It is highly concentrated in muscle and brain tissues. [citation needed] Carnosine was discovered by Russian chemist Vladimir Gulevich.