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Refractory status epilepticus is defined as status epilepticus that continues despite treatment with benzodiazepines and one antiepileptic drug. [ 10 ] Super-refractory status epilepticus is defined as status epilepticus that continues or recurs 24 hours or more after the onset of anaesthetic therapy, including those cases where status ...
[2] [5] It is a type of new-onset refractory status epilepticus (NORSE). [5] The seizures are often resistant to treatment. [2] High doses of benzodiazepines or barbiturates are often used, with care taking place in the intensive care unit. [2] A ketogenic diet may help in some cases. [1] The medications anakinra or tocilizumab have been tried. [2]
The following benzodiazepines are used to treat status epilepticus: Diazepam (1963). Can be given rectally by trained care-givers. Midazolam (N/A). Increasingly being used as an alternative to diazepam. This water-soluble drug is squirted into the side of the mouth but not swallowed. It is rapidly absorbed by the buccal mucosa. Lorazepam (1972 ...
Convulsive status epilepticus that does not respond to initial treatment typically requires admission to the intensive care unit and treatment with stronger agents such as midazolam infusion, ketamine, thiopentone or propofol. [106] Most institutions have a preferred pathway or protocol to be used in a seizure emergency like status epilepticus ...
Marinus Pharmaceuticals Inc (NASDAQ: MRNS) expects data from the RAISE Phase 3 trial of ganaxolone in refractory status epilepticus in 2H of 2023. Earlier data from the trial was expected in 2H of ...
The first-line drugs for treatment of status epilepticus are benzodiazepines, such as lorazepam, clonazepam, midazolam, or diazepam. If these fail, then phenytoin may be used, with phenobarbital being an alternative in the US (favored in infants), but used only third-line in the UK. [21] Failing that, the only treatment is anaesthesia in ...