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Doxycycline was patented in 1957 and came into commercial use in 1967. [7] [8] It is on the World Health Organization's List of Essential Medicines. [9] Doxycycline is available as a generic medicine. [1] [10] In 2022, it was the 68th most commonly prescribed medication in the United States, with more than 9 million prescriptions. [11] [12]
Dairy products, antacids and preparations containing iron should be avoided near the time of taking the drug. Partial exceptions to these rules occur for doxycycline and minocycline, which may be taken with food (though not iron, antacids, or calcium supplements).
It is used as a precursor in the industrial synthesis of doxycycline hyclate. [citation needed] It has been found to act as an agonist of the human pregnane X receptor ligand-binding domain and to induce CYP3A4 expression in vitro. [1]
Heritage Pharmaceuticals Inc. is a manufacturer of generic pharmaceuticals based in Eatontown, New Jersey, United States, and established in 2006. The company was involved in a 2014 congressional inquiry about the rising price of doxycycline hyclate initiated by Elijah Cummings and Bernie Sanders.
A hyclate (Latin: hyclas) is a pharmaceutical term for hydrochloride hemiethanolate hemihydrate [1] [2] (·HCl· 1 / 2 EtOH· 1 / 2 H 2 O), e.g. doxycycline hyclate. [ 3 ] [ 4 ] References
Generic name Origin Susceptible phyla Stage of development Mechanism of action Unclassified Teixobactin: Eleftheria terrae: Gram-positive, including antibiotic resistant S. aureus and M. tuberculosis: No human trials scheduled: Binds fatty acid precursors to cell wall Malacidins: Uncultured Bacterium: Gram-positive, including antibiotic ...