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Between 1910 and 1920, techniques for measuring blood sugar (glucose test) were rapidly improved, allowing experiments to be conducted with greater efficiency and precision. [93] These developments also helped establish the notion that high blood sugar levels (hyperglycemia), rather than glycosuria, was the important condition to be relieved.
Humans can consume a variety of carbohydrates, digestion breaks down complex carbohydrates into simple monomers (monosaccharides): glucose, fructose, mannose and galactose. After resorption in the gut , the monosaccharides are transported, through the portal vein , to the liver, where all non-glucose monosacharids (fructose, galactose) are ...
According to Oxford English Dictionary the specific term glycobiology was coined in 1988 by Prof. Raymond Dwek to recognize the coming together of the traditional disciplines of carbohydrate chemistry and biochemistry. [3] This coming together was as a result of a much greater understanding of the cellular and molecular biology of glycans.
The glucose paradox was the observation that the large amount of glycogen in the liver was not explained by the small amount of glucose absorbed. [1] The explanation was that the majority of glycogen is made from a number of substances other than glucose. [1] The glucose paradox was first formulated by biochemists J. Denis McGarry and Joseph ...
The fluctuation of blood sugar (red) and the sugar-lowering hormone insulin (blue) in humans during the course of a day with three meals. One of the effects of a sugar-rich vs a starch-rich meal is highlighted. [1] The blood sugar level, blood sugar concentration, blood glucose level, or glycemia is the measure of glucose concentrated in the blood.
The microbiome converts fiber into signals that stimulate gut hormones, which in turn control how quickly the stomach empties, regulate blood sugar levels, and influence feelings of hunger. Like all carbohydrates, when fiber is digested, it can produce four calories (kilocalories) of energy per gram, but in most circumstances, it accounts for ...
Chronic hyperglycemia (high blood sugar) injures the heart in patients without a history of heart disease or diabetes and is strongly associated with heart attacks and death in subjects with no coronary heart disease or history of heart failure. [22] Also, a life-threatening consequence of hyperglycemia can be nonketotic hyperosmolar syndrome. [16]
In 1960, the biochemist Robert K. Crane revealed his discovery of the sodium-glucose cotransport as the mechanism for intestinal glucose absorption. [32] This was the very first proposal of a coupling between the fluxes of an ion and a substrate that has been seen as sparking a revolution in biology.