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  2. Active site - Wikipedia

    en.wikipedia.org/wiki/Active_site

    The active site consists of amino acid residues that form temporary bonds with the substrate, the binding site, and residues that catalyse a reaction of that substrate, the catalytic site. Although the active site occupies only ~10–20% of the volume of an enzyme, [ 1 ] : 19 it is the most important part as it directly catalyzes the chemical ...

  3. Active center (polymer science) - Wikipedia

    en.wikipedia.org/wiki/Active_center_(polymer...

    The site on a chain carrier at which reaction occurs. Note: In the Gold Book, [1] the terms “active center” and “active site” are defined with reference to heterogeneous catalysis and the term “reactive site” is used within the definition of chain polymerization.

  4. Catalytic triad - Wikipedia

    en.wikipedia.org/wiki/Catalytic_triad

    The sophistication of the active site network causes residues involved in catalysis (and residues in contact with these) to be highly evolutionarily conserved. [62] However, many examples of divergent evolution in catalytic triads exist, both in the reaction catalysed, and the residues used in catalysis.

  5. Activated complex - Wikipedia

    en.wikipedia.org/wiki/Activated_complex

    In chemistry, an activated complex represents a collection of intermediate structures in a chemical reaction when bonds are breaking and forming. The activated complex is an arrangement of atoms in an arbitrary region near the saddle point of a potential energy surface. [1]

  6. Competitive inhibition - Wikipedia

    en.wikipedia.org/wiki/Competitive_inhibition

    The active site is a region on an enzyme to which a particular protein or substrate can bind. The active site will thus only allow one of the two complexes to bind to the site, either allowing a reaction to occur or yielding it. In competitive inhibition, the inhibitor resembles the substrate, taking its place and binding to the active site of ...

  7. Binding site - Wikipedia

    en.wikipedia.org/wiki/Binding_site

    Binding site in blue, inhibitor in green, and substrate in black. In the scope of cancer, ligands that are edited to have a similar appearance to the natural ligand are used to inhibit tumor growth. For example, Methotrexate, a chemotherapeutic, acts as a competitive inhibitor at the dihydrofolate reductase active site. [40]

  8. Heterogeneous catalysis - Wikipedia

    en.wikipedia.org/wiki/Heterogeneous_catalysis

    The adsorption site is not always an active catalyst site, so reactant molecules must migrate across the surface to an active site. At the active site, reactant molecules will react to form product molecule(s) by following a more energetically facile path through catalytic intermediates (see figure to the right).

  9. Substrate (chemistry) - Wikipedia

    en.wikipedia.org/wiki/Substrate_(chemistry)

    In chemistry, the term substrate is highly context-dependent. [1] Broadly speaking, it can refer either to a chemical species being observed in a chemical reaction, or to a surface on which other chemical reactions or microscopy are performed. In the former sense, a reagent is added to the substrate to generate a product through a chemical ...