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Unlike the other twelve vitamins, vitamin D is only conditionally essential - in a preindustrial society people had adequate exposure to sunlight and the vitamin was a hormone, as the primary natural source of vitamin D was the synthesis of cholecalciferol in the lower layers of the skin’s epidermis, triggered by a photochemical reaction with ...
7-Dehydrocholesterol (7-DHC) is a zoosterol that functions in the serum as a cholesterol precursor, and is photochemically converted to vitamin D 3 in the skin, therefore functioning as provitamin-D 3. The presence of this compound in human skin enables humans to manufacture vitamin D 3 (cholecalciferol).
Cholecalciferol is a form of vitamin D which is naturally synthesized in skin and functions as a pro-hormone, being converted to calcitriol. This is important for maintaining calcium levels and promoting bone health and development. [4] As a medication, cholecalciferol may be taken as a dietary supplement to prevent or to treat vitamin D ...
Ordon reiterates that direct sun exposure — a.k.a. being outside in the sun — can help the body produce enough vitamin D, but for the vast majority of people in the U.S., this is only possible ...
Vitamin D is an important nutrient but one that people tend to lack during the winter months. Vitamin D helps keep bones strong and works to support the body's immune system.. The main way people ...
Because many fungi and protozoa cannot survive without ergosterol, the enzymes that synthesize it have become important targets for drug discovery. In human nutrition, ergosterol is a provitamin form of vitamin D 2; exposure to ultraviolet (UV) light causes a chemical reaction that produces vitamin D 2.
A deficiency occurs if a person doesn't get enough vitamin D from sunlight or food, or if their body can't synthesize or absorb vitamin D properly due to an underlying condition or medication.
Calcitriol is a hormone and the active form of vitamin D, normally made in the kidney. [8] [9] [10] It is also known as 1,25-dihydroxycholecalciferol.It binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes. [11]