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5757 19231 Ensembl ENSG00000187514 ENSMUSG00000026238 UniProt P06454 P26350 RefSeq (mRNA) NM_001099285 NM_002823 NM_008972 RefSeq (protein) NP_001092755 NP_002814 NP_032998 NP_001347759 NP_001347760 Location (UCSC) Chr 2: 231.71 – 231.71 Mb Chr 1: 86.53 – 86.53 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thymosin α 1 is a peptide fragment derived from prothymosin alpha, a ...
Trace amine-associated receptor 1 (TAAR1) is a trace amine-associated receptor (TAAR) protein that in humans is encoded by the TAAR1 gene. [5]TAAR1 is a primarily intracellular amine-activated G s-coupled and G q-coupled G protein-coupled receptor (GPCR) that is primarily expressed in several peripheral organs and cells (e.g., the stomach, small intestine, duodenum, and white blood cells ...
[1] [2] TAAR1, the first of six functional human TAARs, has gained considerable interest in academic and proprietary pharmaceutical research due to its role as the endogenous receptor for the trace amines phenethylamine, tyramine, and tryptamine – metabolic derivatives of the amino acids phenylalanine, tyrosine and tryptophan, respectively ...
Trace amines are an endogenous group of trace amine-associated receptor 1 (TAAR1) agonists [1] – and hence, monoaminergic neuromodulators [2] [3] [4] – that are structurally and metabolically related to classical monoamine neurotransmitters. [5] Compared to the classical monoamines, they are present in trace concentrations. [5]
One of the key features of the TAs is the autoregulation. The antitoxin and toxin protein complex bind to the operator that is present upstream of the TA genes. This results in repression of the TA operon. The key to the regulation are (i) the differential translation of the TA proteins and (ii) differential proteolysis of the TA proteins.
DOTA-TATE can be reacted with the radionuclides gallium-68 (T 1/2 = 68 min), lutetium-177 (T 1/2 = 6.65 d) and copper-64 (T 1/2 = 12.7 h) to form radiopharmaceuticals for positron emission tomography (PET) imaging or radionuclide therapy. 177 Lu DOTA-TATE therapy is a form of peptide receptor radionuclide therapy (PRRT) which targets ...