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A recent large-scale study found that severe depression in patients with bipolar disorder responds no better to a combination of antidepressant medications and mood stabilizers than it does to mood stabilizers alone and that antidepressant use does not hasten the emergence of manic symptoms in patients with bipolar disorder. [40]
In addition, certain features have been shown to increase the chances that depressed patients have a bipolar disorder, including atypical symptoms of depression like hypersomnia and hyperphagia, a family history of bipolar disorder, medication-induced hypomania, recurrent or psychotic depression, antidepressant refractory depression, and early ...
Bipolar disorder is among the top 20 causes of disability worldwide and leads to substantial costs for society. [26] Due to lifestyle choices and the side effects of medications, the risk of death from natural causes such as coronary heart disease in people with bipolar disorder is twice that of the general population. [4]
There are several types of bipolar disorder, which differ by how symptoms present, according to the Mayo Clinic. Bipolar I: People with bipolar I disorder have had at least one manic episode along ...
In a retrospective study of 80 adolescents hospitalized with bipolar disorder, 35% of patients had previously used stimulants and 44% had used antidepressants, where stimulant use was associated with worse hospitalization course. [8] However, there is mixed research on these relationships.
Other disorders need to be ruled out before diagnosing major depressive episodes. Differential diagnoses include, but are not limited to: [24] [7] Adjustment disorder; Anxiety disorder (Generalized anxiety, PTSD, obsessive-compulsive disorder) Bipolar disorder; Bipolar II disorder; Cyclothymic disorder; Depression due to a general medical condition
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