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Cutaneous atrophy in a dog with Cushing's. Cushing's syndrome is classified as either pituitary-dependent, adrenal-dependent, or iatrogenic. [2] Pituitary-dependent Cushing's is caused by an adrenocorticotropic hormone producing pituitary tumour. Adrenal-dependent Cushing's is caused by an adrenal tumour. [4]
"Hyperadrenocorticism (Cushing’s disease) is an overproduction of steroid hormones in the body, caused by a small tumor on the adrenal gland or in the brain. This can lead to thinning of the ...
The symptoms of Cushing's disease are similar to those seen in other causes of Cushing's syndrome. [5] Patients with Cushing's disease usually present with one or more signs and symptoms secondary to the presence of excess cortisol or ACTH. [6] Although uncommon, some patients with Cushing's disease have large pituitary tumors (macroadenomas).
Pituitary gland tumors are very common in the canine. A productive form arising from the anterior pituitary is the primary cause of Cushing's disease of dogs. This tumor causes excessive production of cortisol from the adrenal cortex which leads to the classic signs of alopecia (hair loss), polyuria (excessive urination), polydipsia (excessive water drinking), and a pot-bellied appearance of ...
Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. [4] [9] [10] Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, [11] a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals ...
Trilostane was the first drug approved to treat both pituitary- and adrenal-dependent Cushing's in dogs. [citation needed] Only one other drug, Anipryl (veterinary brand name) selegiline, is FDA-approved to treat Cushing's disease in dogs, but only to treat uncomplicated, pituitary-dependent Cushing's. [30]