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Knee replacement is the most definitive treatment for osteoarthritis-related symptoms and disability. [ 10 ] [ 7 ] It is a type of arthroplasty , and may involve either a partial or total replacement with a prosthesis.
Paradigm's IND application to commence its phase 3 pivotal clinical trial investigating Pentosan Polysulphate Sodium (PPS) for the treatment of pain associated with knee osteoarthritis has been cleared by the US FDA. Approximately 65 sites have been identified throughout the US and Australia. Contracting with many of those sites has been completed.
Osteotomy may be useful in people with knee osteoarthritis, but has not been well studied and it is unclear whether it is more effective than non-surgical treatments or other types of surgery. [144] [145] Arthroscopic surgery is largely not recommended, as it does not improve outcomes in knee osteoarthritis, [146] [147] and may result in harm ...
In fact, knee osteoarthritis is considered to have a high rate of morbidity and disability, according to a study published in August 2023 in the journal Experimental and Therapeutic Medicine.
“Obesity-related knee osteoarthritis is a progressive condition that can lead to pain and ... There is a significant need for non-surgical and sustainable treatment options for those living with ...
Osteoarthritis is often the cause of knee pain, especially for women and older adults, according to the Arthritis Foundation. But sore knees may also result from an injury, weak or tight muscles ...
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