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[1] [2] [3] The vitamins thiamine [4] and cobalamin, [5] and the amino acid tryptophan also contain fragments derived from PRPP. [6] It is formed from ribose 5-phosphate (R5P) by the enzyme ribose-phosphate diphosphokinase: [7] It plays a role in transferring phospho-ribose groups in several reactions, some of which are salvage pathways: [8]
The enzyme is involved in the synthesis of nucleotides (purines and pyrimidines), cofactors NAD and NADP, and amino acids histidine and tryptophan, [1] [2] [3] linking these biosynthetic processes to the pentose phosphate pathway, from which the substrate ribose 5-phosphate is derived. Ribose 5-phosphate is produced by the pentose phosphate ...
Ribose 5-phosphate (R5P) is both a product and an intermediate of the pentose phosphate pathway. The last step of the oxidative reactions in the pentose phosphate pathway is the production of ribulose 5-phosphate. Depending on the body's state, ribulose 5-phosphate can reversibly isomerize to ribose 5-phosphate.
A key regulatory step is the production of 5-phospho-α-D-ribosyl 1-pyrophosphate by ribose-phosphate diphosphokinase, which is activated by inorganic phosphate and inactivated by purine ribonucleotides. It is not the committed step to purine synthesis because PRPP is also used in pyrimidine synthesis and salvage pathways.
The pathway begins with the conversion of Ribose-5-Phosphate(R5P) to phosphoribosyl pyrophosphate (PRPP) by enzyme ribose-phosphate diphosphokinase (PRPS1). PRPP is then converted to 5-phosphoribosylamine (5-PRA) as glutamine donates an amino group to the C-1 of PRPP.
Phosphagen system (ATP-PCr) and purine nucleotide cycle (PNC) [1] The Purine Nucleotide Cycle is a metabolic pathway in protein metabolism requiring the amino acids aspartate and glutamate. The cycle is used to regulate the levels of adenine nucleotides, in which ammonia and fumarate are generated. [2] AMP converts into IMP and the byproduct ...
Histidine is synthesized from phosphoribosyl pyrophosphate (PRPP), which is made from ribose-5-phosphate by ribose-phosphate diphosphokinase in the pentose phosphate pathway. The first reaction of histidine biosynthesis is the condensation of PRPP and adenosine triphosphate (ATP) by the enzyme ATP-phosphoribosyl transferase.
231327 Ensembl ENSG00000128059 ENSMUSG00000029246 UniProt Q06203 Q8CIH9 RefSeq (mRNA) NM_002703 NM_172146 RefSeq (protein) NP_002694 NP_742158 Location (UCSC) Chr 4: 56.39 – 56.44 Mb Chr 5: 77.06 – 77.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Amidophosphoribosyltransferase (ATase), also known as glutamine phosphoribosylpyrophosphate amidotransferase (GPAT), is an enzyme ...