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Eplerenone is an antimineralocorticoid, or an antagonist of the mineralocorticoid receptor (MR). [21] Eplerenone is also known chemically as 9,11α-epoxy-7α-methoxycarbonyl-3-oxo-17α-pregn-4-ene-21,17-carbolactone and "was derived from spironolactone by the introduction of a 9α,11α-epoxy bridge and by substitution of the 17α-thoacetyl ...
Eplerenone is a newer drug that was developed as a spironolactone analog with reduced adverse effects. In addition to the y-lactone ring and the substituent on C-7, eplerenone has a 9α,11α-epoxy group. This group is believed to be the reason why eplerenone has a 20-40-fold lower affinity for the mineralocorticoid receptor than spironolactone. [7]
Potassium-sparing diuretics act to prevent sodium reabsorption in the collecting tubule by either binding ENaCs (amiloride, triamterene) or by inhibiting aldosterone receptors (spironolactone, eplerenone). This prevents excessive excretion of K + in urine and decreased retention of water, preventing hypokalemia. [10]
Amazon launches health monitoring program, partners with Omada Health. Anjalee Khemlani. January 8, 2024 at 5:00 AM.
So Jean enrolled in a theater program at the University of Washington. She fell while filming ‘Mare of Easttown.’ Jean's gotten her fair share of injuries while on the job, too.
Authorities in China said they are monitoring cases of human metapneumovirus, or HMPV, after a reported increase inside the country, according to Reuters.. Although cases are increasing at a rapid ...
Eplerenone, a steroidal antimineralocorticoid of the spirolactone group; Estriol triacetate, an estrogen medication and an estrogen ester
Chuck E. Cheese makes a comeback, with trampolines and a subscription program. Finance. Reuters. Location-tracking company Unacast tells Norway its data was hacked, broadcaster says. Food.