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The HL7 RIM, vocabulary specifications, and model-driven process of analysis and design combine to make HL7 Version 3 one methodology for the development of consensus-based standards for healthcare information systems interoperability. The HDF is the most current edition of the HL7 V3 development methodology.
Clozapine is an effective treatment for those who respond poorly to other drugs ("treatment-resistant" or "refractory" schizophrenia), [142] but it has the potentially serious side effect of agranulocytosis (lowered white blood cell count) in less than 4% of people. [132] [143] [144] Most people on antipsychotics get side effects.