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Eplerenone, sold under the brand name Inspra, is an aldosterone antagonist type of potassium-sparing diuretic that is used to treat chronic heart failure and high blood pressure, particularly for people with resistant hypertension due to elevated aldosterone.
Potassium-sparing diuretics act to prevent sodium reabsorption in the collecting tubule by either binding ENaCs (amiloride, triamterene) or by inhibiting aldosterone receptors (spironolactone, eplerenone). This prevents excessive excretion of K + in urine and decreased retention of water, preventing hypokalemia. [10]
Eplerenone is a newer drug that was developed as a spironolactone analog with reduced adverse effects. In addition to the y-lactone ring and the substituent on C-7, eplerenone has a 9α,11α-epoxy group. This group is believed to be the reason why eplerenone has a 20-40-fold lower affinity for the mineralocorticoid receptor than spironolactone. [7]
When my family moved to New Hampshire going into my freshman year of high school, Dr. C. Everett Koop, President Ronald Reagan’s surgeon general, became my neighbor. As an aspiring doctor, I ...
There are a few possible side effects linked to taking NSAIDs, including: gastrointestinal problems (such as irritation, ulcers, or bleeding), increased risk of heart attack and stroke, reduced ...
Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]
Research shows that older men and women with low testosterone have lower red blood cell counts and an increased risk of developing anemia. Anemia can produce symptoms like fatigue, weakness, loss ...
In medicine and pharmacology, a trough level or trough concentration (C trough) is the concentration reached by a drug immediately before the next dose is administered, [1] [2] often used in therapeutic drug monitoring.