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Frequency. >100,000 per year (US) [ 1 ] Paracetamol poisoning, also known as acetaminophen poisoning, is caused by excessive use of the medication paracetamol (acetaminophen). [ 2 ] Most people have few or non-specific symptoms in the first 24 hours following overdose. These symptoms include feeling tired, abdominal pain, or nausea.
[107] [108] A single dose should not exceed 1000 mg, doses should be taken no sooner than four hours apart, and no more than four doses (4000 mg) in 24 hours. [40] While a majority of adult overdoses are linked to suicide attempts, many cases are accidental, often due to the use of more than one paracetamol-containing product over an extended ...
The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug. It is a comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect. [1] The related terms therapeutic window or safety window refer to a range of doses ...
Timeline of US drug overdose death rates by race and ethnicity. [4] Rate per 100,000 population. The word "overdose" implies that there is a common safe dosage and usage for the drug; therefore, the term is commonly applied only to drugs, not poisons, even though many poisons as well are harmless at a low enough dosage.
Plasma salicylate levels generally range from 30–100 mg/L (3–10 mg/dL) after usual therapeutic doses, 50–300 mg/L in patients taking high doses, and 700–1400 mg/L following acute overdose. [14] Patients may undergo repeated testing until their peak plasma salicylate level can be estimated. [15]
Hypertension develops when the force of the blood coming from your heart consistently puts too much pressure on the walls of your arteries. Over time, this pressure can cause small tears in your ...
Acetylcysteine. N-acetylcysteine, also known as Acetylcysteine and NAC, is a medication that is used to treat paracetamol (acetaminophen) overdose and to loosen thick mucus in individuals with chronic bronchopulmonary disorders such as pneumonia and bronchitis. [9] It has been used to treat lactobezoar in infants.
The minimum dosage at which paracetamol causes toxicity usually is 7.5 to 10g in the average person. [2] The lethal dose is usually between 10 g and 15 g. [citation needed] Concurrent alcohol intake lowers these thresholds significantly. Chronic alcoholics may be more susceptible to adverse effects due to reduced glutathione levels. [3]