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Dabigatran, sold under the brand name Pradaxa among others, is an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. [ 6 ][ 7 ] Specifically it is used to prevent blood clots following hip or knee replacement and in those with a history of prior clots. [ 6 ]
Unlike ximelagatran, a long-term treatment of dabigatran etexilate has not been linked with hepatic toxicity, seeing as how the drug is predominantly eliminated (>80%) by the kidneys. Dabigatran etexilate was approved in Canada and Europe in 2008 for the prevention of VTE in patients undergoing hip- and knee surgery.
Cardiovascular agents are drugs used to treat diseases associated with the heart or blood vessels. These medications are available for purchase only with a physician’s prescription. They include, but are not limited to, drugs that target hypertension (antihypertensives), hyperlipidemia (antihyperlipidemics) and blood clotting (blood-thinners ...
Direct thrombin inhibitors (DTIs) are a class of medication that act as anticoagulants (delaying blood clotting) by directly inhibiting the enzyme thrombin (factor IIa). Some are in clinical use, while others are undergoing clinical development. Several members of the class are expected to replace heparin (and derivatives) and warfarin in ...
Ecarin. Ecarin is an enzyme [1] that is derived from the venom of the Indian saw-scaled viper, Echis carinatus, [2] It is the primary reagent in the Ecarin clotting time test. The venom of the saw-scaled viper, Echis carinatus, causes bleeding and eventually death. The venom contains a metalloprotease called ecarin that converts prothrombin to ...
Common side effects of those drugs can include nausea, diarrhea, stomach pain and vomiting. Lange said the drugmaker has started a Phase 2 trial in people with Type 2 diabetes.