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Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. [1] It occurs when exposure to a substance – specifically, a neurotoxin or neurotoxicant – alters the normal activity of the nervous system in such a ...
This group of persistent health symptoms are called syndrome of irreversible lithium-effectuated neurotoxicity (SILENT). [9] The syndrome presents with irreversible neurological and neuro-psychiatric effects. [10] The neurological signs are cerebellar dysfunction, extrapyramidal symptoms, and brainstem dysfunction. [11]
Toxic encephalopathy is a neurologic disorder caused by exposure to neurotoxic organic solvents such as toluene, following exposure to heavy metals such as manganese, as a side effect of melarsoprol treatment for African trypanosomiasis, adverse effects to prescription drugs, or exposure to extreme concentrations of any natural toxin such as cyanotoxins found in shellfish or freshwater ...
Early neurosyphilis often has no clinical symptoms. Meningitis is the most-common neurological presentation in early syphilis, typically arising within one year of initial infection. [6] Symptoms of syphilitic meningitis are similar to other forms of meningitis, including headache, neck stiffness, photophobia, confusion, nausea, and vomiting. [7]
Neurological signs include impaired vibratory sensation at extremities and an inability to maintain steady motion, a possible effect from psychomotor damage in the brain. Other symptoms that have been seen include fatigue, decreased strength, and unusual gait. [9]
The cerebral atrophy that alcoholics often present with is due to alcohol induced neurotoxicity. [7] [11] Evidence of neurodegeneration can be supported by an increased microglia density and expression of proinflammatory cytokines in the brain. Animal studies find that heavy and regular binge drinking causes neurodegeneration in corticolimbic ...
Signs and symptoms [ edit ] The predominant symptom is peripheral sensory neuropathy [ 26 ] [ 4 ] [ 6 ] [ 27 ] that is experienced as numbness, pins-and-needles and burning sensations ( paresthesia ) in a patient's limbs on both sides of their body.
Common symptoms of TTX consumption include paraesthesia (often restricted to the mouth and limbs), muscle weakness, nausea, and vomiting [55] and often manifest within 30 minutes of ingestion. [57] The primary mechanism by which TTX is toxic is through the inhibition of sodium channel function, which reduces the functional capacity of neuron ...