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  2. Gate control theory - Wikipedia

    en.wikipedia.org/wiki/Gate_control_theory

    Descending pathways also activate opioid receptor-containing parts of the spinal cord. [citation needed] Afferent pathways interfere with each other constructively, so that the brain can control the degree of pain that is perceived, based on which pain stimuli are to be ignored to pursue potential gains.

  3. Presynaptic inhibition - Wikipedia

    en.wikipedia.org/wiki/Presynaptic_inhibition

    A circuit diagram of postsynaptic inhibition (A, B) and presynaptic inhibition (C). Excitation is shown in green and inhibition is shown in red. Presynaptic inhibition is a phenomenon in which an inhibitory neuron provides synaptic input to the axon of another neuron (axo-axonal synapse) to make it less likely to fire an action potential.

  4. Nociceptor - Wikipedia

    en.wikipedia.org/wiki/Nociceptor

    ' pain receptor ') is a sensory neuron that responds to damaging or potentially damaging stimuli by sending "possible threat" signals [1] [2] [3] to the spinal cord and the brain. The brain creates the sensation of pain to direct attention to the body part, so the threat can be mitigated; this process is called nociception .

  5. Pain theories - Wikipedia

    en.wikipedia.org/wiki/Pain_theories

    Descartes' pain pathway: "Particles of heat" (A) activate a spot of skin (B) attached by a fine thread (cc) to a valve in the brain (de) where this activity opens the valve, allowing the animal spirits to flow from a cavity (F) into the muscles causing them to flinch from the stimulus, turn the head and eyes toward the affected body part, and ...

  6. Nociception - Wikipedia

    en.wikipedia.org/wiki/Nociception

    The peduncle is not part of the lateral-spinothalamic-tract-pathway; the medulla receives the info and passes it onto the peduncle from elsewhere (see somatosensory system). The thalamus is where pain is thought to be brought into perception ; it also aids in pain suppression and modulation, acting like a bouncer , allowing certain intensities ...

  7. Autonomic nervous system - Wikipedia

    en.wikipedia.org/wiki/Autonomic_nervous_system

    Autonomic nervous system, showing splanchnic nerves in middle, and the vagus nerve as "X" in blue. The heart and organs below in list to right are regarded as viscera. The autonomic nervous system has been classically divided into the sympathetic nervous system and parasympathetic nervous system only (i.e., exclusively motor).

  8. Referred pain - Wikipedia

    en.wikipedia.org/wiki/Referred_pain

    Referred pain, also called reflective pain, [1] is pain perceived at a location other than the site of the painful stimulus.An example is the case of angina pectoris brought on by a myocardial infarction (heart attack), where pain is often felt in the left side of neck, left shoulder, and back rather than in the thorax (chest), the site of the injury.

  9. Afferent nerve fiber - Wikipedia

    en.wikipedia.org/wiki/Afferent_nerve_fiber

    All of these sensations travel along the same general pathways towards the brain. One pathway—dorsal column–medial lemniscus pathway—begins with sensation from the periphery being sent via afferent nerve fiber of the dorsal root ganglion (first order neuron) through the spinal cord to the dorsal column nuclei (second order neuron) in the ...