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Mephedrone, also known as 4-methylmethcathinone, 4-MMC, and 4-methylephedrone, is a synthetic stimulant drug belonging to the amphetamine and cathinone classes. It is commonly referred to by slang names such as drone, [5] M-CAT, [6] white magic, [7] meow meow, and bubble. [8]
3-Methylmethcathinone (3-MMC), also known as metaphedrone, [4] is a designer drug from the substituted cathinone family. 3-MMC is a monoamine transporter substrate (a substance acted upon by monoamine transporters) that potently releases and inhibits the reuptake of dopamine and norepinephrine, as well as displaying moderate serotonin releasing activity.
In the UK, mephedrone, commonly known as MCAT, is the fourth most commonly used illicit drug among nightclub goers after cannabis, MDMA and cocaine. [7] Based on reports to the American Association of Poison Control Centers , use of bath salts in the US is thought to have increased significantly between 2010 and 2012. [ 7 ]
Methcathinone / ˌ m ɛ θ ˈ k æ θ ɪ ˌ n oʊ n / (α-methyl amino-propiophenone or ephedrone) (sometimes called "cat" or "jeff" or "catnip" or "M-Kat" or "kat" or "intash") is a monoamine alkaloid and psychoactive stimulant, a substituted cathinone.
Effects of 4-CMC and mephedrone on inhibition of neurotransmitter uptake [3] Drug Uptake Inhibition at DAT. IC 50 (nM) Uptake Inhibition at NET. IC 50 (nM) Uptake Inhibition at SERT. IC 50 (nM) Mephedrone 769 ± 106 319 ± 40 600 ± 99 4-CMC 1014 ± 78 559 ± 57 542 ± 38
4-Methylmethcathinone (mephedrone) 58–62.7: 49.1–51: 118.3–122 [11] [8] [14] [15] [16] Notes: The smaller the value, the more strongly the drug releases the neurotransmitter. The assays were done in rat brain synaptosomes and human potencies may be different. See also Monoamine releasing agent § Activity profiles for a larger table with ...
3,4-Dimethylmethcathinone (3,4-DMMC) is a stimulant drug first reported in 2010 as a designer drug analogue of mephedrone, apparently produced in response to the banning of mephedrone, following its widespread abuse in many countries in Europe and around the world. [1] 3,4-DMMC has been seized as a designer drug in Australia. [2]
2-Methylmethcathinone (2-MMC), also known as ortomephedrone is a recreational designer drug with stimulant and euphoric effects. It is a substituted cathinone derivative, closely related to better known drugs such as 3-methylmethcathinone and 4-methylmethcathinone (mephedrone).