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Maggot therapy (also known as larval therapy) is a type of biotherapy involving the introduction of live, disinfected maggots (fly larvae) into non-healing skin and soft-tissue wounds of a human or other animal for the purpose of cleaning out the necrotic (dead) tissue within a wound (debridement), and disinfection.
Allantoin is a chemical compound with formula C 4 H 6 N 4 O 3.It is also called 5-ureidohydantoin or glyoxyldiureide. [1] [2] It is a diureide of glyoxylic acid.Allantoin is a major metabolic intermediate in most organisms including animals, plants and bacteria, though not humans.
Timing is important to wound healing. Critically, the timing of wound re-epithelialization can decide the outcome of the healing. [11] If the epithelization of tissue over a denuded area is slow, a scar will form over many weeks, or months; [12] [13] If the epithelization of a wounded area is fast, the healing will result in regeneration.
The plant parts of Russian comfrey are used for medicinal purposes (mainly because of the allantoin content). They are made into a salve that accelerates wound healing [10] and relieves muscle and joint pain, among other things. [11]
Maggots secrete several chemicals that kill microbes, including allantoin, urea, phenylacetic acid, phenylacetaldehyde, calcium carbonate, proteolytic enzymes, and many others. [12] Maggots were used for wound healing by the Maya and by indigenous Australians.
Debridement is the medical removal of dead, damaged, or infected tissue to improve the healing potential of the remaining healthy tissue. [2] [3] Removal may be surgical, mechanical, chemical, autolytic (self-digestion), or by maggot therapy.
A poultice of the leaves can be applied to wounds, stings, and sores in order to facilitate healing and prevent infection. [medical citation needed] The active chemical constituents are aucubin (an anti-microbial agent), allantoin (which stimulates cellular growth and tissue regeneration), and mucilage (which reduces pain and discomfort).
A week after the injury, the edges of the wound are pulled together by contraction. Contraction is an important part of the healing process when damage has been extensive, and involves shrinking in size of underlying contractile connective tissue, which brings the wound margins toward one another. [1]