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Hematology analyzers are used to conduct a complete blood count (CBC), which is usually the first test requested by physicians to determine a patient's general health status. [5] A complete blood count includes red blood cell (RBC), white blood cell (WBC), hemoglobin , and platelet counts, as well as hematocrit levels.
The Coulter counter is the commercial term for the technique known as resistive pulse sensing or electrical zone sensing. The apparatus is based on the Coulter principle named after its inventor, Wallace H. Coulter. A typical Coulter counter has one or more microchannels that separate two chambers containing electrolyte solutions.
The Coulter principle uses electrical impedance measurements to count blood cells and determine their sizes; it is a technology that remains in use in many automated analyzers. Further research in the 1970s involved the use of optical measurements to count and identify cells, which enabled the automation of the white blood cell differential.
Electrical analysis involves passing a dilute solution of the blood through an aperture across which an electrical current is flowing. The passage of cells through the current changes the impedance between the terminals (the Coulter principle ). [ 6 ]
An impedance analyzer is a type of electronic test equipment used to measure complex electrical impedance as a function of test frequency. Impedance is an important parameter used to characterize electronic components, electronic circuits, and the materials used to make components. Impedance analysis can also be used to characterize materials ...
Often, data obtained by electrochemical impedance spectroscopy (EIS) is expressed graphically in a Bode plot or a Nyquist plot. Impedance is the opposition to the flow of alternating current (AC) in a complex system. A passive complex electrical system comprises both energy dissipater and energy storage elements.
The journal changed from semimonthly (24 times annually) to weekly publication at the start of 2009. It covers clinical and basic research in all areas of hematology, including disorders of leukocytes, both benign and malignant, erythrocytes, platelets, hemostatic mechanisms, vascular biology, immunology, and hematologic oncology.
The current journal, The International Journal of Laboratory Hematology, is the official journal of the ISLH. [3] It provides an international forum for new developments in the practice and research of laboratory hematology and includes invited reviews, original articles, research results, [4] and correspondence. [5]