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Cholecalciferol is a form of vitamin D which is naturally synthesized in skin and functions as a pro-hormone, being converted to calcitriol. This is important for maintaining calcium levels and promoting bone health and development. [4] As a medication, cholecalciferol may be taken as a dietary supplement to prevent or to treat vitamin D ...
Synthesis of vitamin D in nature is dependent on the presence of UV radiation and subsequent activation in the liver and the kidneys. Many animals synthesize vitamin D 3 from 7-dehydrocholesterol, and many fungi synthesize vitamin D 2 from ergosterol. [46] Vitamin D 3 is produced photochemically from 7-dehydrocholesterol in the skin of most ...
Calcitriol is a hormone and the active form of vitamin D, normally made in the kidney. [8] [9] [10] It is also known as 1,25-dihydroxycholecalciferol.It binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes. [11]
7-Dehydrocholesterol (7-DHC) is a zoosterol that functions in the serum as a cholesterol precursor, and is photochemically converted to vitamin D 3 in the skin, therefore functioning as provitamin-D 3. The presence of this compound in human skin enables humans to manufacture vitamin D 3 (cholecalciferol).
cholecalciferol: fat fatty fish (mackerel, salmon, sardines), fish liver oils, eggs from hens fed vitamin D D 4: 22-dihydroergocalciferol: fat D 5: sitocalciferol: fat E: tocopherols, tocotrienols: fat 15 mg/15 mg deficiency is very rare; mild hemolytic anemia in newborn infants [20] possible increased incidence of congestive heart failure. [21 ...
The vitamin D receptor (VDR also known as the calcitriol receptor) is a member of the nuclear receptor family of transcription factors. [5] Calcitriol (the active form of vitamin D , 1,25-(OH) 2 vitamin D 3 ) binds to VDR, which then forms a heterodimer with the retinoid-X receptor .
B vitamins help with cognitive functioning, vitamin D has been linked to better memory and attention span, and omega-3 fatty acids are essential for maintaining healthy brain tissue.
The name 25(OH)D refers to any combination of calcifediol (25-hydroxy-cholecalciferol), derived from vitamin D 3, and ercalcidiol (25-hydroxy-ergocalciferol), [1] derived from vitamin D 2. The first of these (also known as 25-hydroxy vitamin D3) is made by the body, or is sourced from certain animal foods or cholecalciferol supplements.