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Extrapyramidal side effects, although potentially serious, are infrequent to rare from olanzapine, [43] but may include tremors and muscle rigidity. Aripiprazole , asenapine , clozapine , quetiapine and olanzapine, in comparison to other antipsychotic drugs, are less frequently associated with hyperprolactinaemia .
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Uncommon adverse effects of olanzapine, occurring from 0.1–1%, include: Leukopaenia a comparatively low white blood cell (the cells that defend the body from foreign invaders) count. Neutropaenia a reduced neutrophil (the white blood cells that kill bacteria) count. Bradycardia (low heart rate)
The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), [1] [2] are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely introduced after the 1970s and used to treat psychiatric ...
Dopamine receptor flow chart. Dopamine receptors are all G protein–coupled receptors, and are divided into two classes based on which G-protein they are coupled to. [1] The D 1-like class of dopamine receptors is coupled to Gα s/olf and stimulates adenylate cyclase production, whereas the D 2-like class is coupled to Gα i/o and thus inhibits adenylate cyclase production.
[3] [27] [91] Amisulpride, olanzapine, risperidone and clozapine may be more effective but are associated with greater side effects. [92] Typical antipsychotics have equal drop-out and symptom relapse rates to atypicals when used at low to moderate dosages.
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