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Tissue factor, also called platelet tissue factor or Coagulation factor III, [5] is a protein present in subendothelial tissue and leukocytes which plays a major role in coagulation and, in humans, is encoded by F3 gene. Its role in the blood clotting is the initiation of thrombin formation from the zymogen prothrombin.
Tropocollagen molecule: three left-handed procollagens (red, green, blue) join to form a right-handed triple helical tropocollagen. Collagen (/ ˈ k ɒ l ə dʒ ə n /) is the main structural protein in the extracellular matrix of the connective tissues of many animals. It is the most abundant protein in mammals, [1] making up 25% to 35% of ...
1281 12825 Ensembl ENSG00000168542 ENSMUSG00000026043 UniProt P02461 P08121 RefSeq (mRNA) NM_000090 NM_001376916 NM_009930 RefSeq (protein) NP_000081 NP_034060 Location (UCSC) Chr 2: 188.97 – 189.01 Mb Chr 1: 45.35 – 45.39 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Type III Collagen is a homotrimer, or a protein composed of three identical peptide chains (monomers), each ...
The loss of MGMT function leads to a higher rate of mutations, promoting the formation and progression of tumors. The presence or absence of MGMT expression in a cancer sample can indicate a patient's response to alkylating chemotherapy, which is a common treatment for certain types of cancer.
The Golgi apparatus (/ ˈ ɡ ɒ l dʒ i /), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells. [1] Part of the endomembrane system in the cytoplasm, it packages proteins into membrane-bound vesicles inside the cell before the vesicles are sent to their destination.
The p28 subunit, or IL-30, has an important role as a part of IL-27, but it can be secreted as a separate monomer and has its own functions in the absence of EBI3. [ 5 ] [ 6 ] The discovery of IL-30 as individual cytokine is relatively new and thus its role in the modulation of the immune response is not fully understood.
7132 21937 Ensembl ENSG00000067182 ENSMUSG00000030341 UniProt P19438 P25118 RefSeq (mRNA) NM_001065 NM_001346091 NM_001346092 NM_011609 RefSeq (protein) NP_001056 NP_001333020 NP_001333021 NP_035739 Location (UCSC) Chr 12: 6.33 – 6.34 Mb Chr 6: 125.33 – 125.34 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis ...
CD19 is widely expressed during all phases of B cell development until terminal differentiation into plasma cells. During B cell lymphopoiesis, CD19 surface expression starts during immunoglobulin (Ig) gene rearrangement, which coincides during B lineage commitment from hematopoietic stem cell. [8]