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The only progestogens currently used during pregnancy (e.g., for luteal support in IVF protocols or for prevention of preterm birth in pregnant women with a history of at least one spontaneous preterm birth) are: progesterone, hydroxyprogesterone caproate, dydrogesterone, and allylestrenol.
Dydrogesterone, sold under the brand name Duphaston among others, [1] is a progestin medication which is used for a variety of indications, including threatened or recurrent miscarriage during pregnancy, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhea, irregular cycles, premenstrual syndrome, and as a component of menopausal ...
Progesterone (P4), sold under the brand name Prometrium among others, is a medication and naturally occurring steroid hormone. [20] It is a progestogen and is used in combination with estrogens mainly in hormone therapy for menopausal symptoms and low sex hormone levels in women.
Prevention of a miscarriage can sometimes be accomplished by decreasing risk factors. [11] This may include good prenatal care, avoiding drugs and alcohol, preventing infectious diseases, and avoiding X-rays. [11] Identifying the cause of the miscarriage may help prevent future pregnancy loss, especially in cases of recurrent miscarriage.
Certain progestogens are used to support pregnancy, including progesterone, hydroxyprogesterone caproate, dydrogesterone, and allylestrenol. They are used questionably for treatment of recurrent pregnancy loss and for prevention of preterm birth in pregnant women with a history of at least one spontaneous preterm birth. [42]
During implantation and gestation, progesterone appears to decrease the maternal immune response to allow for the acceptance of the pregnancy. [56] Progesterone decreases contractility of the uterine smooth muscle. [54] This effect contributes to prevention of preterm labor. [56]
As for pregnancy hormones in general, there isn’t any research looking into how Ozempic affects hormones related to fertility like estrogen or progesterone. Clinical trials also don’t note any ...
In pregnant women, the elimination half-life of hydroxyprogesterone caproate appears to be longer, about 16 or 17 days. [1] [9] However, in women pregnant with twins rather than a singlet, the elimination half-life of hydroxyprogesterone caproate was found to be shorter than this, at 10 days. [9]