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Myocardial perfusion imaging or scanning (also referred to as MPI or MPS) is a nuclear medicine procedure that illustrates the function of the heart muscle (). [1]It evaluates many heart conditions, such as coronary artery disease (CAD), [2] hypertrophic cardiomyopathy and heart wall motion abnormalities.
Technetium (99m Tc) sestamibi (commonly sestamibi; USP: technetium Tc 99m sestamibi; trade name Cardiolite) is a pharmaceutical agent used in nuclear medicine imaging. The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six (sesta=6) methoxyisobutylisonitrile (MIBI) ligands. The anion is not defined.
Two primary stress tests utilized are a treadmill test using ECG/electrophysiology metrics and nuclear testing, each have unique sensitivity and specificity values. The treadmill test, employing the modified Bruce protocol , [ 20 ] demonstrates a sensitivity range of around 73-90% and a specificity range of around 50-74%.
The modified Bruce Protocol is an alteration in the protocol so that the treadmill is initially horizontal rather than uphill, with the 1st few intervals increasing the treadmill slope only. [3] The Bruce treadmill test estimates maximum oxygen uptake using a formula and the performance of the subject on a treadmill as the workload is increased ...
Johns Hopkins cardiologists analyzed 58,000 heart stress tests to come up with an algorithm called the FIT Treadmill Score. The score factors in peak heart rate and metabolism. The score factors ...
The goal and objectives, the time frame, the stress test level and the total costs of the stress test are defined. Phase 2: Assessment, during which the stress test at the component and the system scope is performed, including fragility [12] and risk [13] analysis of the CIs for the stressors defined in Phase 1. The stress test can result in ...
Scientists charged with ensuring the aging U.S. stockpile of nuclear weapons are good to go — if needed — say they'll start shipping key components to Nevada's desert next year to prepare for ...
The underlying principle is, under conditions of stress, diseased myocardium receives less blood flow than normal myocardium. MPI is one of several types of cardiac stress test. As a nuclear stress test, the average radiation exposure is 9.4 mSv, which when compared with a typical 2 view chest X-ray (.1 mSv) is equivalent to 94 Chest X-rays. [83]