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The use of a nerve decompression or neurectomy to treat nerve pain along the lateral femoral cutaneous nerve is a firmly established surgical treatment. [24] [25] However, the more effective treatment between a decompression and neurectomy is still being researched. Between a nerve decompression and a neurectomy, the neurectomy is associated ...
[12] [13] Neuropathic pain is common in cancer as a direct result of cancer on peripheral nerves (e.g., compression by a tumor), or as a side effect of chemotherapy (chemotherapy-induced peripheral neuropathy), [14] [15] radiation injury or surgery.
Theories of neuropathic pain would inform surgical experimentation, and surgical experimentation would lead to observations or discoveries from which new or modified theories would be developed. By the early 20th century the concept of mononeuropathies due to nerve lesions would be discussed (often called nerve palsy, neuropathy, or neuritis ...
Peripheral neuropathy may be classified according to the number and distribution of nerves affected (mononeuropathy, mononeuritis multiplex, or polyneuropathy), the type of nerve fiber predominantly affected (motor, sensory, autonomic), or the process affecting the nerves; e.g., inflammation (), compression (compression neuropathy), chemotherapy (chemotherapy-induced peripheral neuropathy).
A nerve decompression is a neurosurgical procedure to relieve chronic, direct pressure on a nerve to treat nerve entrapment, a pain syndrome characterized by severe chronic pain and muscle weakness. In this way a nerve decompression targets the underlying pathophysiology of the syndrome and is considered a first-line surgical treatment option ...
Pain in cancer can be produced by mechanical (e.g. pinching) or chemical (e.g. inflammation) stimulation of specialized pain-signalling nerve endings found in most parts of the body (called nociceptive pain), or it may be caused by diseased, damaged or compressed nerves, in which case it is called neuropathic pain. Neuropathic pain is often ...
Bortezomib increases the production of sphingosine-1 phosphate, tumor necrosis factor α, and interleukin-1β, which ultimately leads to the development of neuropathic pain. The side effects of receiving bortezomib include chronic, distal, and symmetrical sensory peripheral neuropathy and neuropathic pain syndrome which may last for weeks ...
H3K9 methylation is an important part of the neuropathic pain pathway. The main markers for chronic neuropathic pain are a rise in excitability in primary afferent neurons and a decrease in potassium channel expression in primary sensory neurons. Peripheral nerve damage causes prolonged downregulation of voltage-gated potassium channels.