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  2. Valsartan - Wikipedia

    en.wikipedia.org/wiki/Valsartan

    The packaging for valsartan includes a warning stating the drug should not be used with the renin inhibitor aliskiren in people with diabetes. It also states the safety of the drug in severe renal impairment has not been established. [7] Valsartan includes a black box warning for fetal toxicity.

  3. Valsartan/hydrochlorothiazide - Wikipedia

    en.wikipedia.org/wiki/Valsartan/hydrochlorothiazide

    Valsartan/hydrochlorothiazide, sold under the brand name Diovan HCT among others, is a medication used to treat high blood pressure when valsartan is not sufficient. [6] It is a combination of valsartan, an angiotensin receptor blocker with hydrochlorothiazide, a diuretic. [7] It is taken by mouth. [7] Common side effects include dizziness and ...

  4. Aliskiren - Wikipedia

    en.wikipedia.org/wiki/Aliskiren

    A warning to avoid use of aliskiren with ARBs or ACEIs was also added for patients with moderate to severe kidney impairment (i.e., where glomerular filtration rate is less than 60 ml/min). [6] Novartis decided to stop marketing Valturna (aliskiren/valsartan). [7] Aliskiren was co-developed by the Swiss pharmaceutical companies Novartis and ...

  5. Sacubitril/valsartan - Wikipedia

    en.wikipedia.org/wiki/Sacubitril/valsartan

    Sacubitril/valsartan, sold under the brand name Entresto among others, is a fixed-dose combination medication for use in heart failure. It consists of the neprilysin inhibitor sacubitril and the angiotensin receptor blocker valsartan .

  6. Renin inhibitor - Wikipedia

    en.wikipedia.org/wiki/Renin_inhibitor

    Aliskiren is effective in lowering blood pressure, [7] [28] but as of 20 April 2012 the US Food and Drug Administration (FDA) issued a warning of possible risks when using aliskiren or blood pressure medicines containing aliskiren with ACE inhibitors and angiotensin receptor blockers (ARBs) in patients with diabetes or kidney (renal) impairment.

  7. Amlodipine/valsartan - Wikipedia

    en.wikipedia.org/wiki/Amlodipine/valsartan

    Amlodipine/valsartan, sold under the brand name Exforge among others, is a blood pressure lowering combination drug. It contains amlodipine , as the besilate, a dihydropyridine -type calcium channel blocker , and valsartan , an angiotensin II receptor antagonist . [ 6 ]

  8. Losartan/hydrochlorothiazide - Wikipedia

    en.wikipedia.org/wiki/Losartan/hydrochlorothiazide

    Losartan/hydrochlorothiazide, sold under the brand name Hyzaar among others, is a fixed-dose combination medication used to treat high blood pressure when losartan is not sufficient.

  9. Discovery and development of angiotensin receptor blockers

    en.wikipedia.org/wiki/Discovery_and_development...

    Losartan, valsartan, candesartan, irbesartan, telmisartan and olmesartan all contain a biphenyl-methyl group. Losartan is partly metabolized to its 5- carboxylic acid metabolite EXP 3174, which is a more potent AT 1 receptor antagonist than its parent compound [ 17 ] and has been a model for the continuing development of several other ARBs.