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Collagen-induced arthritis (CIA) is a condition induced in mice (or rats) to study rheumatoid arthritis. [1] CIA is induced in mice by injecting them with an emulsion of complete Freund's adjuvant and type II collagen. [2] In rats, only one injection is needed, but mice are normally injected twice. [3]
Type II collagen is the basis for hyaline cartilage, including the articular cartilages at joint surfaces. It is formed by homotrimers of collagen, type II, alpha 1 chains. It makes up 50% of all protein in cartilage and 85–90% of collagen of articular cartilage.
Collagens are complex molecules that provide structure, strength, and elasticity to connective tissue. Type II and type XI collagen disorders are grouped together because both types of collagen are components of the cartilage found in joints and the spinal column, the inner ear, and the jelly-like substance that fills the eyeball (the vitreous ...
If you live with arthritis, it can impact everything from your mobility to your sleep quality and overall wellness. "Arthritis occurs when there's swelling or inflammation in a joint or tissue ...
Prevalent throughout the body, loss of collagen can also contribute to numerous other disorders such as joint pain, weakened hair and nails, reduced bone density, gastrointestinal issues, and reduced muscle mass. Numerous interventions exist to address the loss of collagen with varying levels of efficacy and evidentiary support.
Collagen is also abundant in corneas, blood vessels, the gut, intervertebral discs, and the dentin in teeth. [3] In muscle tissue, it serves as a major component of the endomysium. Collagen constitutes 1% to 2% of muscle tissue and 6% by weight of skeletal muscle. [4] The fibroblast is the most common cell creating collagen in animals.
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