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Septic shock is a subclass of distributive shock, a condition in which abnormal distribution of blood flow in the smallest blood vessels results in inadequate blood supply to the body tissues, resulting in ischemia and organ dysfunction. Septic shock refers specifically to distributive shock due to sepsis as a result of infection. [14]
SIRS is a serious condition related to systemic inflammation, organ dysfunction, and organ failure. It is a subset of cytokine storm, in which there is abnormal regulation of various cytokines. [6] SIRS is also closely related to sepsis, in which patients satisfy criteria for SIRS and have a suspected or proven infection. [2] [3] [4] [7]
Severe sepsis causes poor organ function or blood flow. [9] The presence of low blood pressure, high blood lactate, or low urine output may suggest poor blood flow. [9] Septic shock is low blood pressure due to sepsis that does not improve after fluid replacement. [9] Sepsis is caused by many organisms including bacteria, viruses, and fungi. [10]
Neurogenic shock is caused by the loss of vascular tone normally supported by the sympathetic nervous system due to injury to the central nervous system especially spinal cord injury. [4] [6] Rupture of a hollow organ, with subsequent evacuation of contents in the peritoneal cavity could also determine neurogenic shock, a subtype of ...
Organ failure is organ dysfunction to such a degree that normal homeostasis cannot be maintained without external clinical intervention or life support. It is not a diagnosis. It is not a diagnosis. It can be classified by the cause, but when the cause is not known, it can also be classified by whether the onset is chronic or acute .
This is especially the case if the sepsis gets worse, and even more if it becomes severe sepsis (where organ damage begins), septic shock (the organ damage continues, which lowers the blood pressure to the point where special drugs are needed to help keep it high enough), or multiple organ dysfunction syndrome (where organ damage can quickly ...
A common cause of sepsis is bacterial pneumonia, frequently the result of infection with streptococcus pneumoniae. Patients with sepsis require intensive care with blood pressure monitoring and support against hypotension. Sepsis can cause liver, kidney and heart damage. Respiratory failure - CAP patients often have dyspnea, which may require ...
Both SIRS and sepsis could ultimately progress to multiple organ dysfunction syndrome. In one-third of the patients, however, no primary focus can be found. [1] Multiple organ dysfunction syndrome is well established as the final stage of a continuum: SIRS + infection → sepsis → severe sepsis → Multiple organ dysfunction syndrome.