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Pergolide, sold under the brand name Permax and Prascend (veterinary) among others, is an ergoline-based dopamine receptor agonist used in some countries for the treatment of Parkinson's disease. Parkinson's disease is associated with reduced dopamine synthesis in the substantia nigra of the brain .
pergolide – dopamine receptor agonist used for the treatment of pituitary pars intermedia dysfunction in horses; phenobarbital – anti-convulsant used for seizures; phenylbutazone – nonsteroidal anti-inflammatory drug (NSAID) phenylpropanolamine – controls urinary incontinence in dogs
Equine estrogens are found in the human medications conjugated estrogens (Premarin) and esterified estrogens (Estratab, Menest). [1] [2] [3.
Newer synthetic ergoline derivatives that have been synthesized for the treatment of Parkinson's disease include pergolide and lisuride, which both act as dopamine agonists as well. [ 28 ] A famous ergoline derivative is the psychedelic drug LSD , a semi-synthetic ergoline alkaloid that was discovered by Albert Hofmann.
Ponazuril (), sold by Merial, Inc., [1] now part of Boehringer Ingelheim, [2] under the trade name Marquis (15% w/w ponazuril), is a drug currently approved for the treatment of equine protozoal myeloencephalitis (EPM) in horses, caused by coccidia Sarcocystis neurona.
Horses are most often dewormed with a paste or gel placed on the back of the animal's mouth via a dosing syringe; feed dewormers are also used, both single-dose varieties and in a daily, "continuous" feed form. Deworming (drenching) a sheep is usually done with a specific drenching gun that squirts an anthelmintic into the sheep's throat ...
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