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DMPA, under brand names such as Depo-Provera and Depo-SubQ Provera 104, is used in hormonal birth control as a long-lasting progestogen-only injectable contraceptive to prevent pregnancy in women. [ 38 ] [ 39 ] It is given by intramuscular or subcutaneous injection and forms a long-lasting depot , from which it is slowly released over a period ...
Medroxyprogesterone acetate (brand names Depo-Provera, Provera, Depo-subQ Provera 104) [4] – 150 mg (intramuscularly) or 104 mg (subcutaneously) every 3 months [3] Norethisterone enanthate (brand names NET EN, Noristerat, Norigest, Doryxas) [ 5 ] – 200 mg (intramuscularly) every 2 months [ 3 ]
Depot MPA (DMPA) and EC/MPA were developed by Upjohn in the 1960s. [12] [13] DMPA (brand name Depo-Provera) was introduced for use as a progestogen-only injectable contraceptive for the first time outside of the United States in 1969 and was subsequently approved for use in birth control in the United States in 1992.
Compared to MPA, medroxyprogesterone is over two orders of magnitude less potent as a progestogen. [8] Medroxyprogesterone is also notable in that it is a minor metabolite of MPA. [ 9 ] In addition to its progestagenic activity, medroxyprogesterone is a weak antiandrogen in vitro on human androgen receptor .
The first progestogen-only contraceptive was introduced in 1969: Depo-Provera, a high-dose progestin injection. [54] Over the next decade and a half, other types of progestogen-only contraceptive were developed: a low-dose progestogen only pill (1973); [ 55 ] Progestasert, the first hormonal intrauterine device (1976); [ 56 ] and Norplant , the ...
0.65 0.45–0.94 −7 / 10,000 PYs ... studies have certain advantages over the aforementioned ... suppress circulating testosterone levels in men by up to 70 to 80% ...