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The Multiple Sclerosis Journal (formerly Multiple Sclerosis) is a monthly peer-reviewed medical journal covering the clinical neurology of multiple sclerosis. The editor-in-chief is Alan J Thompson (University College London). It was established in 1995 and is published by SAGE Publications. [1]
Research in multiple sclerosis may find new pathways to interact with the disease, improve function, curtail attacks, or limit the progression of the underlying disease. Many treatments already in clinical trials involve drugs that are used in other diseases or medications that have not been designed specifically for multiple sclerosis .
The Multiple Sclerosis Functional Composite (MSFC) is a clinical trial outcome measure of assessing the severity of multiple sclerosis primarily used in research. [1] The score is based on a combination of timed tests of walking , arm function, and cognitive ability . [ 1 ]
John Francis Kurtzke (September 14, 1926 – December 1, 2015) was a neuroepidemiologist and Professor of Neurology at Georgetown University who is best known for his creation of the Expanded Disability Status Scale and for his research on multiple sclerosis (MS). [1]
In multiple sclerosis, inflammation, demyelination, and neurodegeneration are observed together. Some clinical trials have shown that the inflammation produces both the relapses and the demyelination, and that neurodegeneration (axonal transection) is independent from inflammation, produces the accumulative disability, and advances even when ...
The Kurtzke Expanded Disability Status Scale (EDSS) is a method of quantifying disability in multiple sclerosis. [1] [2] The scale has been developed by John F. Kurtzke. [1] The EDSS is based on a neurological examination by a clinician. However, a number of versions have been developed which enable patient self-administration. [3]
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