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The central dogma of molecular biology deals with the flow of genetic information within a biological system. It is often stated as "DNA makes RNA, and RNA makes protein", [1] although this is not its original meaning. It was first stated by Francis Crick in 1957, [2] [3] then published in 1958: [4] [5] The Central Dogma.
According to the central dogma of molecular biology, the DNA in a cell is transcribed to produce RNA, which is then translated to produce a protein. Thousands of proteins are encoded in an organism's genome, and the proteins present in a cell cooperatively carry out many functions to support the life of the cell. Under various conditions, such ...
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The Enchiridion (full title: Enchiridion symbolorum, definitionum et declarationum de rebus fidei et morum; "A handbook of symbols, definitions and declarations on matters of faith and morals"), usually translated as The Sources of Catholic Dogma, is a compendium of texts on Catholic theology and morality. This compendium was first published in ...
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In 1956 Francis Crick described the flow of genetic information from DNA to a specific amino acid arrangement for making a protein as the central dogma. [1] For a cell to properly function, proteins are required to be produced accurately for structural and for catalytic activities.
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Initiation of translation is regulated by the accessibility of ribosomes to the Shine-Dalgarno sequence. This stretch of four to nine purine residues are located upstream the initiation codon and hybridize to a pyrimidine-rich sequence near the 3' end of the 16S RNA within the 30S bacterial ribosomal subunit . [ 1 ]