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Haemophilia B, also spelled hemophilia B, is a blood clotting disorder causing easy bruising and bleeding due to an inherited mutation of the gene for factor IX, and resulting in a deficiency of factor IX. It is less common than factor VIII deficiency (haemophilia A). [3] Haemophilia B was first recognized as a distinct disease entity in 1952. [4]
Haemophilia can be diagnosed before, during or after birth if there is a family history of the condition. Several options are available to parents. If there is no family history of haemophilia, it is usually only diagnosed when a child begins to walk or crawl. Affected children may experience joint bleeds or easy bruising. [36]
Platelet storage pool deficiency is a family of clotting disorders characterized by deficient granules in platelets. Individuals with these disorders have too few or abnormally functioning alpha granules , delta granules , or both alpha and delta granules and are therefore unable to form effective clots, which leads to prolonged bleeding.
Other more serious bruising culprits are kidney and liver malfunction, leukemia, or a vitamin K deficiency, which affect’s the blood’s ability to clot, she adds. How to treat bruises and help ...
The two most common signs and symptoms of bone marrow failure are bleeding and bruising. Blood may be seen throughout the gums, nose or the skin, and bleeding tends to last longer than normal. Children have a greater chance of seeing blood in their urine or stools, which results in digestive problems with an unpleasant scent.
This compromises the effectiveness of treatment since treatment of the disease is often aimed at the underlying cause. [ 39 ] Those with a higher risk for aplastic anemia include individuals who are exposed to high-dose radiation or toxic chemicals, take certain prescription drugs, have pre-existing autoimmune disorders or blood diseases, or ...
Wiskott–Aldrich syndrome, where they may resemble a few bruises [4] Acute leukemia [5] Chronic leukemia [5] Vitamin K deficiency [6] Purpura and ecchymoses: Acute leukemia [5] Chronic leukemia [5] Vitamin K deficiency [6] Blood in stool: Wiskott–Aldrich syndrome, especially in infancy [4] Acute leukemia [5] Bleeding gingiva (gums) Wiskott ...
Causes for reactive thrombocythemia in children are similar to adults. In addition, hemolytic anemia and thalassemia are often present in children living in the Middle East. Other causes of reactive thrombocythemia include: post surgery, iron deficiency, drugs, and rebound effect after bone marrow suppression. [8]