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Acute promyelocytic leukemia represents 10–12% of AML cases. [16] The median age is approximately 30–40 years, [33] which is considerably younger than the other subtypes of AML (70 years), however in elderly population APL has peculiar characteristics. [34] Incidence is higher among individuals of Latin American or South European origin. [35]
All subtypes except acute promyelocytic leukemia are usually given induction chemotherapy with cytarabine and an anthracycline such as daunorubicin or idarubicin. [60] This induction chemotherapy regimen is known as " 7+3 " (or "3+7"), because the cytarabine is given as a continuous IV infusion for seven consecutive days while the anthracycline ...
Acute myelogenous leukemia (AML) occurs far more commonly in adults than in children, and more commonly in men than women. It is treated with chemotherapy. The five-year survival rate is 20%. [19] Subtypes of AML include acute promyelocytic leukemia, acute myeloblastic leukemia, and acute megakaryoblastic leukemia.
Acute promyelocytic leukemia (APL) is a specific type of AML. In this leukemia promyelocytes are produced and build up in the bone marrow. A specific chromosome translocation (a type of genetic change) is found in patients with APL. Genes on chromosome 15 change places with genes on chromosome 17.
"The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials" (PDF). Blood. 98 (6): 1752– 1759.
Acute myelomonocytic leukemia (AMML) is a form of acute myeloid leukemia that involves a proliferation of CFU-GM myeloblasts and monoblasts.AMML occurs with a rapid increase amount in white blood cell count and is defined by more than 20% of myeloblast in the bone marrow.
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