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Once it is produced, pancreatic polypeptide is shown to be a 36 amino acid long peptide that can be sent out to different areas within the pancreas or organism. [6] Pancreatic polypeptide cells are most active and secrete more pancreatic polypeptide after a meal with high protein, fasting, physical activity, and acute hypoglycemia.
Pancreatic polypeptide regulates pancreatic secretion activities by both endocrine and exocrine tissues. It also affects hepatic glycogen levels and gastrointestinal secretions. Its secretion in humans is increased after a protein meal, fasting , exercise, and acute hypoglycaemia , and is decreased by somatostatin and intravenous glucose .
Peptide YY 3-36 (PYY) is a linear polypeptide consisting of 34 amino acids with structural homology to NPY and pancreatic polypeptide. The PP-fold motif is found throughout this family and relates to the 3D structure. The PP-fold is formed through the incorporation of certain residues which are predominately Pro2, Pro5, Pro8, Gly9, Tyr20 and Tyr27.
The endocrine cells constitute the beta cells which make insulin, alpha cells which secrete glucagon, delta cells which secrete somatostatin and the PP-cells which secrete pancreatic polypeptide. [3] Pancreatic progenitor cells have been shown to arise from cells originating from the developing foregut during mammalian development.
Endocytosis is a cellular process in which substances are brought into the cell. The material to be internalized is surrounded by an area of cell membrane, which then buds off inside the cell to form a vesicle containing the ingested materials. Endocytosis includes pinocytosis (cell drinking) and phagocytosis (cell eating). It is a form of ...
Metabolism (/ m ə ˈ t æ b ə l ɪ z ə m /, from Greek: μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms.The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks of proteins, lipids, nucleic acids, and some carbohydrates; and the ...
In biochemistry, lipogenesis is the conversion of fatty acids and glycerol into fats, or a metabolic process through which acetyl-CoA is converted to triglyceride for storage in fat. [1] Lipogenesis encompasses both fatty acid and triglyceride synthesis , with the latter being the process by which fatty acids are esterified to glycerol before ...
In cell biology, a vesicle is a structure within or outside a cell, consisting of liquid or cytoplasm enclosed by a lipid bilayer. Vesicles form naturally during the processes of secretion , uptake (endocytosis), and the transport of materials within the plasma membrane.
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